p53 is the most famous cancer gene, not least because it’s involved in causing over 50% of all cancers. When a cell loses its p53 gene—when the gene becomes mutated—it unleashes many processes that lead to the uncontrolled cell growth and refusal to die, which are hallmarks of cancer growth. But there are some cancers, like kidney cancer, that that had few p53 mutations. In order to understand…
Nature Cell Biology – Wang, Wilfahrt and colleagues show that phosphoethanolamine, a phospholipid intermediate, is enriched in tumour interstitial fluid and induces T cell dysfunction,…
Nature Human Behaviour – Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function…
Nature Immunology – Stunnenberg et al. use a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune…
Nature Human Behaviour – How does the brain encode complex movement sequences? Qi et al. reveal that the brain decomposes sequences into temporal states, each…
Hexosamine synthesis pathway and SCAP/SREBP-1 reciprocally enhance each other to drive malignant brain tumor growth.
A global study by experts at the University of Sydney has shown that countries that consume more plant-based proteins—such as chickpeas, tofu and peas—have longer…
Translational Psychiatry – Healthy sleep patterns and risk of hospitalization for infection: a large community-based cohort study
Nature Communications – Here, the authors characterize the epigenetic status of hybrid ecDNA in HPVOPC, identifying HPV oncogenes E6/E7 in hybrid ecDNA are flanked by…
This cross-sectional study analyzes the use of 10 no-cost preventive services by individuals with employer-sponsored health insurance, which may be threatened by the upcoming Kennedy…
Annals of Biomedical Engineering – High-frequency irreversible electroporation (H-FIRE) is a minimally invasive local ablation therapy known to activate the adaptive immune system and reprogram…
