Ribosome-targeting drugs are widely used in basic research and medicine, yet the conservation of their binding residues in bacterial ribosomes remains unknown. Here, Ekemezie et al. reveal extensive sequence divergence in ribosomal drug-binding sites across bacterial lineages, offering a resource for more optimized applications of ribosome-targeting drugs.
Biomimetic in vitro models that more accurately replicate tumor and microenvironmental complexity are transforming radiotherapy research. Unlike traditional 2D cell lines, 3D models such as…
Liu et al. show that the choline transporters SLC44A1/5 are required for oligodendrocyte differentiation and myelination in mouse postnatal brains. Specifically, SLC44A1 deletion in oligodendrocytes…
Despite KRAS G12V being a common mutation in cancer, no direct inhibitors currently exist. Stanland et al. demonstrate that an EGFR-directed RNAi platform, EFTX-G12V, selectively…
Li et al. use single nucleus sequencing of 217 large B cell lymphomas to identify microenvironment archetype profiles (LymphoMAPs), discovering their divergent biology and association…
Single-cell digital embryo reconstruction during early organogenesis creates spatiotemporal atlases for mesoderm and endoderm lineages and captures the primordium determination zone (PDZ) at the E7.75…
Despite KRAS G12V being a common mutation in cancer, no direct inhibitors currently exist. Stanland et al. demonstrate that an EGFR-directed RNAi platform, EFTX-G12V, selectively…
Saleme et al. show that cancer’s stress resistance is driven by translation of hyperacute response proteins from m6A-tagged mRNAs within minutes of various stresses (metabolic…
Wang et al. reconstructed the Trebouxiophyceae phylogeny and identified incomplete lineage sorting as the primary cause of gene tree heterogeneity. They underscored the pivotal role…
Multiple exposures to an evolving virus can drive antibody affinity maturation toward cross-reactivity. How viruses continue to evolve despite these broad antibodies is unclear. Maurer…
Indigenous Orang Asli of Peninsular Malaysia raised concerns about the etiology, treatment, and transmission routes of the skin disorder tinea imbricata. Analyses of the associated…
