Four-month treatment with GDS may improve endothelial glycocalyx and vascular function after COVID-19 infection.

Elevated lipoprotein(a) [Lp(a)] has emerged as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve stenosis (AVS). A new study found that low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB), and high-sensitivity C-reactive protein (hsCRP) explain a minimal or negligible fraction of this risk.

• Cumulative CV health score at age 18 to 45 years was tied to reduced CVD risk at midlife.
• Individuals who improved yearly cumulative Life’s Essential 8 score by midlife also shared in the CV benefit.

Our study showed that poultry consumption above 300 g/week is associated with a statistically significant increased mortality risk both from all causes and from GCs. The risk is higher for men than for women.

The retrospective cohort study presented at ACC 2025 analyzed more than 917,000 diabetic patients without CAD using the TriNetX database. After propensity score matching, colchicine use was associated with:

• 21% reduction in all-cause mortality (OR, 0.79; P<0.001);
• 89% reduction in acute myocardial infarction (OR, 0.11; P<0.001); and
• 37% reduction in cerebrovascular accidents (OR, 0.63; P<0.001).

Using coronary artery calcium (CAC) scores to guide treatment is associated with significant benefits for intermediate-risk patients with a family history of premature coronary artery disease (CAD), according to new data published in JAMA.[1]

Up to 50% of all patients face an intermediate risk of developing CAD, researchers explained, and the optimal treatment strategy for that population remains unclear. The issues is made even more challenging by the fact that medications and lifestyle interventions are not always effective in intermediate-risk patients. 

New evidence highlights how diet quality, not just plant-based eating, can influence breast cancer risk, particularly in postmenopausal women and those with lower BMI.

The Tau protein is essential for neuron function (via stabilizing microtubules) but with damage it can undergo excessive phosphorylation at over 80 sites, one of which is at threonine (T) 217 in the proline rich domain (Figure). The hyperphosphorylation disrupts Tau’s function, the basis for forming neurofibrillary tangles, a precursor to Alzheimer’s disease.

New research from the University of Sydney links fatty, sugary diets to impaired brain function. The findings build on a growing body of evidence showing the negative impact of high-fat, high-sugar (HFHS) diets on cognitive ability, adding to their well-known physical effects.