Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
Zhang et al. determined human OAT1 structures in the apo state and bound to probenecid, adefovir, cefazolin, and PAH, revealing a planar ligand-binding mode. Distinctly,…
A personalized neoantigen peptide vaccine formulated with Montanide plus poly-ICLC and administered with local ipilimumab plus systemic nivolumab induces robust neoepitope-specific T cell responses and…
Galan-Cobo et al. demonstrate that KRAS-mutant non-small cell lung cancers with STK11/LKB1 and KEAP1 co-occurring alterations show a dependency on ATR-CHK1 signaling. They present preclinical…
Hsiao et al. show that T cells in human CNS compartments exhibit distinct tissue-residency programs. Using flow cytometry, transcriptomics, and in vitro assays, the study…
Imagine a virtual copy of you helping doctors predict and prevent health issues. I’m on @9news sharing how digital twin technology could revolutionize your c…
Swapping out the brain’s immune cells can slow progression of a devastating neurological disease
Significant progress has been made in recent years in applying large language models and multimodal artificial intelligence to health and medicine, transforming diagnostics, patient interactions,…
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Despite initial forays into clinical settings, single-cell technologies do not yet routinely inform medical decision-making. Here, we identify and categorize barriers hindering the clinical deployment…
A personalized neoantigen peptide vaccine formulated with Montanide plus poly-ICLC and administered with local ipilimumab plus systemic nivolumab induces robust neoepitope-specific T cell responses and…
