Myofibroblasts are important mediators of wound healing but can also perpetuate fibrosis in diseases such as systemic sclerosis by evading apoptosis. Therapeutic targeting of the survival mechanisms used by these cells in fibrotic disease holds promise for the reversal of fibrosis.
Nature Reviews Rheumatology – In a phase III trial, the addition of obinutuzumab to standard therapy for lupus nephritis led to an increase in the…
Nature Reviews Rheumatology – Research demonstrates that the SARS-CoV-2 protein ORF8 drives osteoclastogenesis, establishing a direct link between viral infection and bone loss.
Nature Reviews Rheumatology – Garrido-Mesa and Brown review findings from TCR profiling studies in rheumatic diseases and discuss how improved study design might help elicit…
Nature Reviews Rheumatology – The mechanisms that drive the diverse disease manifestations and increased cancer risk associated with systemic sclerosis are unclear. Investigating the genomic…
Nature Reviews Rheumatology – This Review discusses the current evidence for the association between occupational exposures, particularly silica dust and solvents, and the risk of…
Nature Reviews Rheumatology – A mouse model that reflects Sjögren disease in humans provides insights into the role of regulatory T cells and type 1…
Nature Reviews Rheumatology – The detection of anellovirus or eHHV-6B genomes in the blood virome seems to correlate with the risk or severity of rheumatic…
Nature Reviews Rheumatology – This Review summarizes lessons learned from the use of rituximab in patients with systemic lupus erythematosus, and discusses the future of…
Nature Reviews Rheumatology – This Review summarizes lessons learned from the use of rituximab in patients with systemic lupus erythematosus, and discusses the future of…
Glucocorticoid-induced osteoporosis (GIOP) lacks fully effective treatments. This study investigated the role of Piezo1, a mechanosensitive ion channel component 1, in GIOP. We found reduced…
