Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.
Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living…
The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.
Causal inference has recently garnered significant interest among recommender system (RS) researchers due to its ability to dissect cause-and-effect relationships and its broad applicability across…
Nipah virus is a zoonotic virus that spills over to humans and causes infections with a high mortality rate. Deep mutational scanning of the Nipah…
Aguilar-Gómez et al. find evidence of evolutionary adaptation with potential relevance to breath-hold diving in the Haenyeo divers of Korea. Genetic variants under selection in this…
To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a…
Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.
Intestinal T cells will recognize self-, diet-, and microbiota-derived antigens to effectively promote tolerance. Here, Yi and Jung et al. present a hierarchical TCR classification to reveal…
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in…
In recent years, plant science research has increasingly embraced interdisciplinary approaches, integrating knowledge and techniques from genomics, bioinformatics, synthetic biology, chemistry, materials science, artificial intelligence,…
