Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment
Green et al. establish a multiomic single-cell atlas of antigen-specific CD8+ T cell states across infection and cancer, revealing enhancer-driven gene regulatory networks governing CD8+ T cell differentiation and tissue adaptation. They demonstrate that molecular programs of tissue-resident CD8+ T cells support TIL accumulation and anti-tumor activity in solid tumor settings.
