Electrocardiometry for the Management of Pediatric Septic… : Critical Care Explorations
Randomized control trial. SETTING: PICU in a tertiary care hospital. PATIENTS: Children from 2 months to 18 years with sepsis and unresolved shock after the initial fluid bolus (FB). INTERVENTIONS: Children were randomized to one of the two groups, that is, electrocardiometry with clinical monitoring group (group B) and clinical monitoring alone group (group A). In group B, electrocardiometry variables (cardiac index and systemic vascular resistance index) along with clinical monitoring were used to guide FB, as well as selection and titration of vasoactive agents. Clinical parameters were used to initiate and titrate fluid resuscitation and vasoactive therapy in group A as per standard guidelines. MEASUREMENTS AND MAIN RESULTS: One hundred nineteen children were enrolled in the study: 60 in group A and 59 in group B. There was a significantly higher requirement for resuscitation fluid volume (mean ± sd) within the initial 6 hours in the group A (30 ± 8.2 mL/kg) as compared with group
