Yang et al. show that the dCas13 system is capable of labeling RNAs. Applying orthogonal dCas13s or combining with dCas9 allows simultaneous visualization of RNA-RNA and DNA-RNA in living cells. The dCas13 system is user friendly in real-time RNA imaging without requiring genetic manipulation.
Nature Communications – Ancestral bias in cancer genomic datasets limits the effectiveness of precision medicine. Here, the authors introduce PhyloFrame, a machine learning framework that…
Nature Biotechnology – Society, patients and clinicians welcome a much-needed non-opioid pain medication. Vertex’s first-in-class analgesic Journavx could soon be followed by a new generation…
Nature Biotechnology – Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.
After offering a deep dive last year into the recipe behind its lead lung fibrosis candidate, Insilico Medicine is now giving a tour of its…
Pharma companies have warned that the lowered prices will mean less drug innovation.
Nature Biotechnology – The first clinical results in patients with a genetic form of frontotemporal dementia (FTD) show that enhancing progranulin in the brain may…
Alan Aspuru-Guzik, director of Acceleration Consortium at the University of Toronto, discusses his research in targeting an ‘undruggable’ cancer protein with the help from AI…
Session I Chairs: Monika Holubová (Charles University, Czech Republic), Dominik Schneidawind (University Hospital Zurich, Switzerland) Charles University, Czech Republic CiRT co-founder University of Pennsylvania, United…
Scientists used implanted fat cells to gobble up available nutrients around cancer tumors, starving the tumors to death.
Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery…
