Donor regulatory T-cell therapy to prevent graft-versus-host disease
Key PointsTreg-engineered donor graft prevents acute and chronic GVHD.Patients treated with Treg-engineered graft who develop GVHD respond to primary corti
Key PointsTreg-engineered donor graft prevents acute and chronic GVHD.Patients treated with Treg-engineered graft who develop GVHD respond to primary corti
We report eight patients with ANKRD26-related thrombocytopenia-2 (ANKRD26-RT) with elevated bone marrow myeloblasts and dysmegakaryopoiesis, without somati
We report eight patients with ANKRD26-related thrombocytopenia-2 (ANKRD26-RT) with elevated bone marrow myeloblasts and dysmegakaryopoiesis, without somati
Key PointsA stem cell–like cell of origin imparts high GATA2 expression in AML cells.GATA2 plays a direct role in modulating p53-induced apoptosis via the
Key Points. Revumenib exhibited a promising complete response rate and manageable safety profile in patients with NPM1-mutated relapsed/refractory AMLRespo
Key PointsPD-L1 expression is increased in 46/1 haplotype carriers.3D chromatin structure differs between JAK2 haplotypes, and noncoding elements in the JA
Key PointsThe overall frequency of BTK mutations was low in zanubrutinib- and ibrutinib-treated patients experiencing early CLL progression in the ALPINE s
Key PointsTemporal single-cell RNA sequencing of mouse blood identifies nonintuitive signatures of IL-17 and CSF-1 dysregulation during cGVHD.Analogous IL-
Key PointsIn this dose-finding phase 1 study, quercetin, a natural antioxidant was found to be safe and well tolerated in patients with FA.ROS levels decre
Rong He, Dong Chen; Myelodysplastic neoplasm with biallelic TP53 inactivation in a patient with plasma cell myeloma after cytotoxic therapy. Blood 2025; 145 (19): 2230.…
In this Letter to the Editor, Shyam A. Patel, MD, PhD, discusses the dependence academic institutions have on federal funding for research and where investigators…