This randomized clinical trial compares the effects of dexmedetomidine- or clonidine-based sedation vs propofol-based sedation (usual care) on the duration of mechanical ventilation in critically ill adults.
This randomized clinical trial compares the effects of dexmedetomidine- or clonidine-based sedation vs propofol-based sedation (usual care) on the duration of mechanical ventilation in critically…
This narrative review summarizes the pathophysiology, epidemiology, diagnosis, and treatment of immune thrombotic thrombocytopenic purpura.
This cross-sectional study analyzed 9 years of data from Hong Kong schoolchildren to report the prevalence of refractive astigmatism and corneal astigmatism and explore the…
The OCEAN(a)-DOSE multicenter randomized clinical trial among 281 patients with atherosclerotic cardiovascular disease assesses the effects of olpasiran on oxidized phospholipids, high-sensitivity interleukin 6, and…
This systematic review aims to identify and critically appraise the quality of the measurement properties of existing alopecia areata–specific patient-reported outcome measures and to provide…
This cohort study examines the association between adjuvant chemoradiotherapy and overall survival compared with radiotherapy alone in patients with intermediate-risk cervical cancer.
This randomized clinical trial examines the relative effect of 4 classes of glucose-lowering medications that were randomly added to metformin on cognitive performance in persons…
Critically ill patients receiving invasive mechanical ventilation often require continuous infusion of sedation to address pain and anxiety. The search for the single best sedative…
This systematic review and meta-analysis assesses reports of clinical experiences of patients with COVID-19 and immunosuppression who were treated with specific neutralizing antibodies via COVID-19…
The urgent response to the COVID-19 pandemic has highlighted the importance of diverse, real-world data sources, such as electronic health records, insurance claims, and patient…
