The ideal first-line treatment of cisplatin-ineligible patients with metastatic urothelial carcinoma (mUC) remains unknown pending results of randomized trials. Although mUC tumours are sensitive to chemotherapy, response durations are short. A new retrospective study provides data on the effectiveness of first-line PD-1/PD-L1 inhibitors compared with carboplatin-based chemotherapy in this…
Oncogene – Human CSPG4-targeting CAR-macrophages inhibit melanoma growth
Nature Communications – Ancestral bias in cancer genomic datasets limits the effectiveness of precision medicine. Here, the authors introduce PhyloFrame, a machine learning framework that…
Nature Medicine – Exploratory post hoc analysis of molecular residual disease from the ADAURA trial of adjuvant osimertinib in patients with resected EGFR-mutated stage IB–IIIA…
Journal of Perinatology – Management of the patent ductus arteriosus among infants born at 23 to 32 weeks’ gestation between 2011 to 2022: a report…
Scientific Reports – Unique events improve episodic richness, enhance mood, and alter the perception of time during isolation
Nature Communications – Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new…
Nature Reviews Gastroenterology & Hepatology – The burden of liver disorders increases worldwide as does the necessity for new treatments. This Review discusses cell therapy…
Scientific Reports – An osteobiography of a celebrity chimpanzee reflects the changing roles of modern zoos
Nature Reviews Cancer – ALK genetic alterations drive various malignancies through aberrant tyrosine kinase activation, promoting oncogenic cell growth and survival. Here, Voena et al.…
Nature Neuroscience – Cholinergic interneurons act at nicotinic receptors to depress dopamine release, interrupting its relationship to dopamine neuron firing and supporting an inverse scaling…
