Subclonal evolution allows tumors to evade the immune system. In this issue of Cancer Cell, Dijkstra et al. combine the TRACERx cohort with co-cultures of autologous tumors and immune cells to functionally profile subclonal immune escape at the single-clone resolution. This work highlights cancer-intrinsic immune-escape mechanisms that can be interrogated on a co-culture platform.
Wafik El-Deiry: Collaboration in US and Global Fight Against Cancer / cancer, Mark Halperin, NCI, NIH, OncoDaily, Oncology, Patrick Soon-Shiong, Precision
The decision comes after a Supreme Court ruling allowing the Trump administration to slash the federal work force and dismantle agencies.
Vitiello et al. describe how the chemotherapy combination of cisplatin and temozolomide fosters anti-tumor immune surveillance by remodeling the immune microenvironment, inducing hypermutation, and generating…
Our medical establishment told people to “Stop Trusting the Public Health Establishment”. Now, almost no one trusts our medical establishment.
CD8 T cell activation and acquisition of cytolytic activity, which is essential for adaptive immunity, begins with priming in the lymph node (LN). Jobin et…
FOXP3+ regulatory T cells (Tregs) are essential for maintaining immune tolerance, and their dysfunction is a hallmark of autoimmune diseases. Recent studies have identified key…
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptional condensates to enable…
Wei et al. demonstrate that a ketogenic diet induces oxidative stress and cellular senescence in an estrogen-dependent manner, with effects seen in male, but not…
Climate change has led animal species to shift their ranges to greater elevations, latitudes, and depths, tracking their preferred abiotic niche. However, there is extensive…
