Considerations for the Next Clinical Trial Evaluating the Role of Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma

The SWOG 8949 and EORTC 30947 trials established the role of cytoreductive nephrectomy. The CARMENA trial calls into question the need for cytoreductive nephrectomy. We describe a phase 3 trial of cytoreductive nephrectomy in patients receiving modern immunotherapy.

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