Recapitulating the concurrent development of germ layers through the co-differentiation of mesoderm and endoderm within a single spheroid enabled the generation of vascularized lung and intestinal organoids, revealing how the microenvironment guides the development of organotypic endothelial and mesenchymal cells.
Daman et al. show that bladder administration of BCG, a microbial immunotherapy for bladder cancer, triggers a systemic immune response, reprogramming HSPCs and resulting in…
Development of a comprehensive cell-type-specific enhancer-AAV toolkit enables targeted dissection of cortical cell types in the primate brain.
Zhang et al. identify a circulating T cell receptor (TCR) signature enriched in nasopharyngeal carcinoma (NPC) patients, enabling early cancer detection in EBV-seropositive at-risk individuals…
Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists,…
Spreckels et al. study human milk oligosaccharides and milk microbiota in Lifelines NEXT families. Human milk has an individual-specific composition, which is affected by maternal…
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This Matters Arising paper questions a prior study describing a mechanism of GTP utilization in polymerase-mediated mRNA capping by the coronavirus SARS-CoV-2 and suggests that…
Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists,…
(Cell Reports 44, 115963; July 22, 2025)
(Cell Reports 42, 112937; August 29, 2023)
