Clinical efficacy of different therapeutic options for knee osteoarthritis: A network meta-analysis based on randomized clinical trials
Objective To assess and compare the clinical efficacy of various therapeutic options in treating patients with knee osteoarthritis (KOA). Methods We performed a comprehensive search of PubMed, Embase, OVID, Cochrane Library and Web of Science databases from their inception to December 10th, 2023, identifying randomized controlled trials (RCTs) examining the effects of therapeutic options on KOA. Two researchers independently performed literature screening, data extraction, data collection and organization, and quality assessment. The data obtained were subjected to statistical analysis and graphical representation using Stata 17.0 software. Results A total of 139 RCTs encompassing 9644 KOA patients and involving 12 therapeutic options were included. These interventions were low level laser therapy (LLLT), high intensity laser therapy (HILT), transcutaneous electrical nerve stimulation (TENS), interferential current (IFC), short wave diathermy, ultrasound, lateral wedged insole, knee br
