Clec10a regulates mite-induced dermatitis

House dust mite (HDM) is an allergen associated with a variety of diseases, including asthma and atopic dermatitis (AD). The NC/Nga mouse strain develops severe AD in response to HDM, and Kanemaru et al. have now identified a stop-gain mutation, the Clec10a C-type lectin receptor, that is associated with this response. HDM-induced dermatitis was driven by TLR4-mediated inflammatory responses, and…

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