B cells can assume protective or pathogenic roles in immune-mediated diseases (IMDs). Analysis of the B cell receptor (BCR) repertoires in six IMDs provides insights into the diversity of B cell repertoires across diseases as well as into potential pathological mechanisms and the effects of different treatments.
Nature Reviews Rheumatology – In a phase III trial, the addition of obinutuzumab to standard therapy for lupus nephritis led to an increase in the…
Nature Reviews Rheumatology – Research demonstrates that the SARS-CoV-2 protein ORF8 drives osteoclastogenesis, establishing a direct link between viral infection and bone loss.
Nature Reviews Rheumatology – Garrido-Mesa and Brown review findings from TCR profiling studies in rheumatic diseases and discuss how improved study design might help elicit…
Nature Reviews Rheumatology – The mechanisms that drive the diverse disease manifestations and increased cancer risk associated with systemic sclerosis are unclear. Investigating the genomic…
Nature Reviews Rheumatology – This Review discusses the current evidence for the association between occupational exposures, particularly silica dust and solvents, and the risk of…
Nature Reviews Rheumatology – A mouse model that reflects Sjögren disease in humans provides insights into the role of regulatory T cells and type 1…
Nature Reviews Rheumatology – The detection of anellovirus or eHHV-6B genomes in the blood virome seems to correlate with the risk or severity of rheumatic…
Nature Reviews Rheumatology – This Review summarizes lessons learned from the use of rituximab in patients with systemic lupus erythematosus, and discusses the future of…
Nature Reviews Rheumatology – This Review summarizes lessons learned from the use of rituximab in patients with systemic lupus erythematosus, and discusses the future of…
Glucocorticoid-induced osteoporosis (GIOP) lacks fully effective treatments. This study investigated the role of Piezo1, a mechanosensitive ion channel component 1, in GIOP. We found reduced…
