GLP-1R agonists may reduce cardiometabolic complications in part through reduction of inflammation. Here we show, using pharmacology and genetics, that the anti-inflammatory actions of GLP-1RAs to reduce TLR-mediated inflammation require CNS GLP-1R signaling.
Meyer et al. identify a poor-prognosis basoluminal tumor cell phenotype in triple-negative breast cancer. Favorably prognostic are tumor-CD8+ T cell interactions, HLADR expression on tumor…
Molina et al. show that transcription factors of the MYB68 subclade promote cork differentiation in the Arabidopsis root. On the one hand, they activate suberin…
Wang et al. present a Janus adhesive hydrogel scaffold with an inverse opal microstructure that provides adhesion in the intestinal environment. The integrated multi-channel sensor…
Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.
Subclonal evolution allows tumors to evade the immune system. In this issue of Cancer Cell, Dijkstra et al. combine the TRACERx cohort with co-cultures of…
Blackburne et al. track the electroencephalogram activity of volunteers inhaling a high dose of the powerful psychedelic 5-methoxy-N,N-dimethyltryptamine, revealing profoundly slowed-down brain activity but no…
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent…
Díaz et al. demonstrate that mechanical injury to the surface of the cornea induces temporary expression of an opsin photoreceptor, Opn5, in mice and primates.…
In this issue of Cancer Cell, Meyer et al. use imaging mass cytometry and identify a stem-like basoluminal tumor cell linked to poor prognosis in…
The “Rising Stars in Plant Sciences” (RSPS) Award co-hosted annually by Molecular Plant and its sister journal, Plant Communications, since 2022, aims to recognize excellent…
