GLP-1R agonists may reduce cardiometabolic complications in part through reduction of inflammation. Here we show, using pharmacology and genetics, that the anti-inflammatory actions of GLP-1RAs to reduce TLR-mediated inflammation require CNS GLP-1R signaling.
Rising heat stress due to climate warming poses a significant threat to human health, and greenness offers a nature-based solution to mitigate heat-related health impacts…
Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease caused by motor neuron loss. In a recent Phase 2b trial, Bensimon and colleagues report that…
Circadian rhythms are key regulators of immune functions. These endogenous oscillations help to maintain immune homeostasis, regulate responses to pathogens, and shape vaccine efficacy. Recent…
High-diversity LoxCode barcoding enables in vivo clonal lineage tracing at both bulk- and single-cell resolutions and provides fresh insights into clonality in early murine development.
Cancers are complex, diverse, and elusive, with extrachromosomal DNA (ecDNA) recently emerging as a crucial player in driving the evolution of about 20% of all…
Identification of exendin-4 (a glucagon-like peptide 1 receptor agonist, GLP-1RA) in Gila monster venom may be regarded as one of the most serendipitous discoveries of…
Phospholipase effectors of the CBASS system assemble from an inactive dimeric state into active higher-order filamentous oligomers upon sensing cyclic dinucleotides, facilitating membrane disruption and…
Despite plenty of studies on the change in thyroid hormones after stroke, there is still no consensus for a comprehensive conclusion and clinical application. This…
Zhang et al. highlight the role of peptides in crosstalk and metabolic processes. They discuss the history of peptide discovery and recent advances in peptidomics,…
The CCR5delta32 deletion arose on a pre-existing haplotype of 84 variants over 6,700 years ago in the Western Steppe. Positive selection drove it to high…
