Lab-grown brain organoids developed from a patient’s own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it. A new study in Cell from researchers at Penn Medicine showed how glioblastoma organoids could serve as effective models to rapidly test personalized treatment strategies.
For some, the word “histamine” might evoke thoughts of seasonal allergies: runny noses, scratchy throats and itchy eyes. But the molecule also influences exercise performance.
As generic versions of AstraZeneca’s blockbuster drug ticagrelor prepare to enter the market, The BMJ raises fresh concerns over the integrity of the clinical trials…
Nature Nanotechnology – Engineered pyroptotic vesicles formed during tumour cell pyroptosis and engineered as personalized tumour vaccines can activate a robust antitumour immune response for…
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a public health concern, linked with immune-metabolic dysfunction. While lifestyle and dietary modifications remain the cornerstone of…
Nature Communications – Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts…
The anti-aging drug rapamycin has the same life-extending effect as eating less, according to new research from the University of East Anglia and University of…
Nature Communications – While switch-like expression (“on” in some individuals and “off” in others) has been linked to biological variation and disease susceptibility, a…
Background Head impacts, particularly, non-concussive impacts, are common in sport. Yet, their effects on the brain remain poorly understood. Here, we investigated the acute effects…
Objective To assess and compare the clinical efficacy of various therapeutic options in treating patients with knee osteoarthritis (KOA). Methods We performed a comprehensive search…
Nature Neuroscience – Some neurons act like body-proximity sensors. The authors show that these neurons reflect the value of contacting or avoiding objects. Together, these…
