Key PointsBCL11A disruption impairs erythroid precursor expansion in vitro and after xenotransplantation into immunodeficient mice.BCL11A regulates at leas
Recent molecular and diagnostic advances in acute myeloid leukemia (AML) have led investigators and clinicians to further categorize patients in different
In this issue of Blood, Sun et al address a critical question regarding the link between diabetes and the progression of glomerular filtration rate in…
Key Pointsβ-thal erythroblasts display persistent compensatory expression of PKM2.Mitapivat mitigates Cys-oxidative damage to β-thal erythroblast proteins,
The recent decision by the American Society of Hematology (ASH) Executive Committee to adopt formally and uniformly the term “classical hematology” instead of “
In this issue of Blood, Nguyen et al report that models of germinal center (GC)-derived B-cell lymphoma (BCL) display synthetic vulnerability to combined i
Thomas R. Collins is a medical journalist based in West Palm Beach, Florida. The combination of the BTK inhibitor zanubrutinib and the BCL2 inhibitor venetoclax…
Key Points. Biallelic disruption of CD38 is a rare but recurrent phenomenon in anti-CD38 exposed relapsed/refractory multiple myeloma.Mutations in CD38 can
In this issue of Blood, Zaiken et al provide compelling evidence that Tet3 deficiency in donor T cells promotes the differentiation of interleukin-4 (IL-4)
Key PointsRenal impairment and enhanced venous thrombosis in Townes AS mice mimic similar complications in humans with SCT.Nephropathy and increased size o
Key PointsCNS relapse rate in HGBCL-DH-BCL2 (6.8% at 2 years) is much lower than previously reported and is associated with clinical risk factors.DZsig ref
