Bone turnover and risk of fracture are orchestrated by homeostatic functions of osteoclast–osteoblast bone remodelling units. Anabolic and antiresorptive drugs used to treat and prevent fractures have differing effects on remodelling defects, but which class of drug is the preferred front-line therapy?
Nature Reviews Rheumatology – Calcium pyrophosphate deposition (CPPD) disease is secondary to the pathological accumulation of calcium pyrophosphate (CPP) crystals inside joints and involves acute…
Nature Reviews Rheumatology – Altered metabolism of the tricarboxylic acid cycle metabolite fumarate drives activation of interferon release in systemic sclerosis monocytes, suggesting a potential…
Nature Reviews Rheumatology – In the phase III SELECT-GCA trial, upadacitinib at a dose of 15 mg daily was superior to placebo with respect to…
Nature Reviews Rheumatology – Lipid nanoparticle carriers of immunosuppressive mRNA shape tolerogenic antigen-presenting cells that inhibit arthritis progression in mice.
Nature Reviews Rheumatology – A simple blood test that can diagnose or predict one’s risk for autoimmune diseases would revolutionize medicine and transform patient care.…
Nature Reviews Rheumatology – Although autoimmune rheumatic diseases are more prevalent in women than men, few clinical trials report findings on the basis of sex…
Nature Reviews Rheumatology – IgG4-related disease is a fibro-inflammatory disorder with a complex pathogenesis. Herein the authors review the latest developments in IgG4-related disease clinical…
Nature Reviews Rheumatology – In a phase III trial, the addition of obinutuzumab to standard therapy for lupus nephritis led to an increase in the…
Nature Reviews Rheumatology – Research demonstrates that the SARS-CoV-2 protein ORF8 drives osteoclastogenesis, establishing a direct link between viral infection and bone loss.
Nature Reviews Rheumatology – Garrido-Mesa and Brown review findings from TCR profiling studies in rheumatic diseases and discuss how improved study design might help elicit…
