And the biggest scientific breakthrough of 2019 is …
Science chooses the top scientific achievement of the year, plus nine runners-up
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Microglia replacement halts the progression of microgliopathy in mice and humans
Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy with axonal…
Spatiotemporal reconstruction of the North American A(H5N1) outbreak reveals successive lineage replacements by descendant reassortants
Phylodynamics show the reassortant progeny of Eurasian H5 clade 2.3.4.4b and American LPAI viruses outcompeted their ancestors.
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors
Cd69 mRNA levels distinguish potent and dysfunctional activation among CD69+ CD8 T cells in tumors.
I thought imposter syndrome caused my Ph.D. struggles. I was wrong
This former graduate student felt like a fish out of water—until she discovered her true passion
A new path to migraine
Cerebrospinal fluid influx directly activates trigeminal neurons in a migraine model
Growth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repair
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa.
Cascading land surface hazards as a nexus in the Earth system
This Review synthesizes progress and outlines a new framework for understanding how land surface hazards interact and propagate as sediment cascades across Earth’s surface, influenced…
Chimpanzee drumming may give clues to the roots of rhythm
Behavior is more complex than scientists realized, could reveal origins of musicality
Global shark fishing mortality still rising despite widespread regulatory change
Sharks continue to be overexploited by fisheries despite widespread legislation that reduced wasteful shark-finning practices.
SRT-H: A hierarchical framework for autonomous surgery via language-conditioned imitation learning
A language-guided imitation learning framework achieves step-level autonomy in robotic cholecystectomy surgeries.