Advancing geoscience: The Innovation
A collection of The Innovation cutting edge papers exploring important topics centered around geoscience.
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Tracing the evolutionary history of the CCR5delta32 deletion via ancient and modern genomes
The CCR5delta32 deletion arose on a pre-existing haplotype of 84 variants over 6,700 years ago in the Western Steppe. Positive selection drove it to high…
m6A alters ribosome dynamics to initiate mRNA degradation
m6A is a potent inducer of ribosome stalling and collisions that trigger YTHDF-mediated mRNA degradation, a process that highlights the ribosome as a critical sensor…
Repurposing of old drugs for unleashing innate immunity
Pharmacological activation of the stimulator of interferon genes (STING) pathway triggers inflammatory innate immune responses to potentially reinvigorate tumor immunogenicity. Recent work by Dang et…
Neuro–immune crosstalk: focus on innate lymphoid cells
Neuro–immune crosstalk regulates inflammation and host metabolism via neural modulation of innate lymphoid cells (ILCs). Significant knowledge gaps remain regarding the signaling pathways, regulators, and…
GZMK+CD8+ T cells: multifaceted roles beyond cytotoxicity
CD8+ T cells, traditionally recognized for their cytotoxic role in eliminating infections and malignancies, are now known to exhibit significant functional heterogeneity, as revealed by…
A natural gene on-off system confers field thermotolerance for grain quality and yield in rice
A natural variation in QT12, a negative regulator of field thermotolerance controlled by upstream NF-Y transcription factors, leads to its insensitive response to high temperature,…
The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
Flaherty et al. demonstrate that the catalytic efficiency of METTL16 regulates expression of MAT2A to determine the intracellular SAM setpoint. Their data indicate that this…
Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4
Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an…
tRNA modifications tune m6A-dependent mRNA decay
tRNA modifications functionally interact with m6A to regulate mRNA decay.
A miR156-SPL module controls shade-induced inhibition of vascular cambium activity through cytokinin pathway in poplar
How high stand density and shade regulate cambial activity and wood formation in perennial trees remains unclear. Wei et al. demonstrate that, in Populus, the…