A Study of the CD73 Inhibitor LY3475070 Alone or in Combination With Pembrolizumab in Participants With Advanced Cancer – Full Text View.
Upregulation of a cluster of primate-specific KRAB zinc finger proteins in cancer cells prevents replicative stress and inflammation by regulating heterochromatin maintenance, which could facilitate…
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Dhungel et al. report an alternate receptor for AAV (AAVR2, carboxypeptidase D), which is distinct from the multi-serotype AAV receptor (AAVR). This study provides insights…
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Cancers are complex, diverse, and elusive, with extrachromosomal DNA (ecDNA) recently emerging as a crucial player in driving the evolution of about 20% of all…
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bles from radiology reports. Methods: A single center retrospective study included patients under surveillance for pancreatic cysts. Nine radiographic elements used to monitor cyst progression…
Signal Transduction and Targeted Therapy – CAR-T cell therapy for cancer: current challenges and future directions
Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor…
