Organisms must adapt to unpredictable environmental perturbations. We propose that the immune system, which can be redistributed across tissues (‘immune innervation’), cooperates with the nervous system to form a larger integrative network that can maximize the number of adaptive physiologic states to a given perturbation.
(Cell Reports 22, 3277–3291; March 20, 2018)
Oligo-LiveFISH is an approach that can track diverse genomic loci at high spatial (20 nm) and temporal (50 ms) resolution and can work in diverse…
The quantification of physical properties of biological matter gives rise to novel ways of understanding functional mechanisms. One of the basic biophysical properties is the…
Nguyen et al. demonstrate that variation in inverted repeats within C. difficile’s flagellar switch impacts the phase-variable expression of flagellar genes, which contributes to the…
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination,…
CAR T cell therapy can cause cognitive impairment in mouse models with central nervous system (CNS) and non-CNS cancers by inducing persistent neuroinflammation, thereby disrupting…
Arginine availability and metabolism critically shape tumor-immune interactions. In this issue of Cancer Cell, Zhu et al. demonstrate that breast cancer-cell-derived arginine synthesized via ASS1 fuels…
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination,…
Pool et al. demonstrate PKA RIβ phase separation and evaluate how its condensates are dysregulated by two neurological disease mutations. Both Marbach-Schaaf neurodevelopmental syndrome variant…
Wu and Nowakowski review the progression of in vitro human brain models, highlighting the applications of assembloids in studying development and disease. They further discuss the…
