Despite initial forays into clinical settings, single-cell technologies do not yet routinely inform medical decision-making. Here, we identify and categorize barriers hindering the clinical deployment of single-cell omics. We articulate a framework to identify patient subpopulations that stand to benefit from such biomarkers and outline the requirements to derive actionable clinical readouts.
Pharmacological activation of the stimulator of interferon genes (STING) pathway triggers inflammatory innate immune responses to potentially reinvigorate tumor immunogenicity. Recent work by Dang et…
Neuro–immune crosstalk regulates inflammation and host metabolism via neural modulation of innate lymphoid cells (ILCs). Significant knowledge gaps remain regarding the signaling pathways, regulators, and…
CD8+ T cells, traditionally recognized for their cytotoxic role in eliminating infections and malignancies, are now known to exhibit significant functional heterogeneity, as revealed by…
A natural variation in QT12, a negative regulator of field thermotolerance controlled by upstream NF-Y transcription factors, leads to its insensitive response to high temperature,…
Flaherty et al. demonstrate that the catalytic efficiency of METTL16 regulates expression of MAT2A to determine the intracellular SAM setpoint. Their data indicate that this…
Summer parties are in full swing! I’m on @9news breaking down how much is too much when it comes to alcohol, plus smart tips to…
Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an…
tRNA modifications functionally interact with m6A to regulate mRNA decay.
How high stand density and shade regulate cambial activity and wood formation in perennial trees remains unclear. Wei et al. demonstrate that, in Populus, the…
Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription…
