CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases

The impact of neutrophil maturation in refractory tumors such as bone metastases remains underexplored. Shi et al. demonstrate that predominant immature neutrophils inhibit anti-tumor immunity in the bone metastasis microenvironment through DKK1-CKAP4-CHI3L3 signaling. Restoring neutrophil maturation via DKK1 blockade reduces tumor burden and enhances ICB response in bone metastases.

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Categories: General Medicine News

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