Chadarevian et al. show that human iPSC-microglia (iMG) can be engineered ex vivo to enable pathology-responsive and CNS-wide delivery of therapeutic proteins. Their findings suggest that iMG could offer a promising new platform technology to deliver biological therapeutics throughout the brain.
An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or…
Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes with single-amino-acid resolution.
The plant auxin influx carrier AUX1 plays a critical role in polar auxin transport. This study resolve two cryo-EM structures of Arabidopsis AUX1 in apo…
Follicular lymphoma is a neoplastic disease of B cell-rich follicular structures of lymphoid origin. In this issue of Cancer Cell, Abe et al. use multi-omics…
Follicular lymphoma is a neoplastic disease of B cell-rich follicular structures of lymphoid origin. In this issue of Cancer Cell, Abe et al. use multi-omics…
SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and…
Parasitology; Public health; Ecology; Zoology; Entomology
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal…
Xie et al. identify that Clostridium butyricum enhances anti-PD-1 efficacy in colorectal cancer (CRC) and propose the use of this probiotic as an adjuvant for…
Aberrant splicing of microexons yields non-canonical surface receptors, such as the neuronal cell adhesion molecule (NRCAM) lacking amino acids encoded by exons 5 and 19.…
