Average Annual Total Expenses, Total Utilization, and Sources of Payment for Outpatient Prescription Opioids in the U.S. Adult Civilian Noninstitutionalized Population, 2021-2022
In 2021-2022, average annual total outpatient prescription opioid expenses for adults were $3.5 billion, with oxycodone and hydrocodone together accounting for nearly 75 percent of total spending ($1.9 and $0.7 billion, respectively). Total outpatient prescription opioid fills for adults totaled 68.6 million, with hydrocodone, oxycodone, and tramadol accounting for the majority of these fills (25.2 million, 19.2 million, and 14.1 million fills, respectively). Average annual total spending per person with
