Advancing geoscience: The Innovation
A collection of The Innovation cutting edge papers exploring important topics centered around geoscience.
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Low-dose IL-2 reinvigorates the immunoguardians of neurodegenerative diseases
Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease caused by motor neuron loss. In a recent Phase 2b trial, Bensimon and colleagues report that…
Development of a circadian immune system
Circadian rhythms are key regulators of immune functions. These endogenous oscillations help to maintain immune homeostasis, regulate responses to pathogens, and shape vaccine efficacy. Recent…
LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs
High-diversity LoxCode barcoding enables in vivo clonal lineage tracing at both bulk- and single-cell resolutions and provides fresh insights into clonality in early murine development.
Extrachromosomal DNA: shaping the evolutionary dynamics of cancer
Cancers are complex, diverse, and elusive, with extrachromosomal DNA (ecDNA) recently emerging as a crucial player in driving the evolution of about 20% of all…
Glucagon-like peptide-1 receptor agonism and end-organ protection
Identification of exendin-4 (a glucagon-like peptide 1 receptor agonist, GLP-1RA) in Gila monster venom may be regarded as one of the most serendipitous discoveries of…
Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation
GLP-1R agonists may reduce cardiometabolic complications in part through reduction of inflammation. Here we show, using pharmacology and genetics, that the anti-inflammatory actions of GLP-1RAs…
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity
Phospholipase effectors of the CBASS system assemble from an inactive dimeric state into active higher-order filamentous oligomers upon sensing cyclic dinucleotides, facilitating membrane disruption and…
Thyroid hormones and neurological impairments during the first two days after stroke: A pilot study
Despite plenty of studies on the change in thyroid hormones after stroke, there is still no consensus for a comprehensive conclusion and clinical application. This…
Discovery of peptides as key regulators of metabolic and cardiovascular crosstalk
Zhang et al. highlight the role of peptides in crosstalk and metabolic processes. They discuss the history of peptide discovery and recent advances in peptidomics,…
Tracing the evolutionary history of the CCR5delta32 deletion via ancient and modern genomes
The CCR5delta32 deletion arose on a pre-existing haplotype of 84 variants over 6,700 years ago in the Western Steppe. Positive selection drove it to high…