Single-cell digital embryo reconstruction during early organogenesis creates spatiotemporal atlases for mesoderm and endoderm lineages and captures the primordium determination zone (PDZ) at the E7.75 embryonic-extraembryonic interface, where cross-germ-layer signaling communication drives organogenesis.
D’Ignazio et al. developed ventral forebrain organoids to model the caudate nucleus of X-linked dystonia parkinsonism patients. A thorough characterization led to the identification of…
Hu et al. identify gut mycobiome-based enterotypes (favorable type and unfavorable type) associated with immunotherapy response. Favorable-type enterotypes, characterized by higher microbial diversity and enriched…
Han et al. provide evidence suggesting that global brain activity and its coupling with CSF inflow are correlated with tau deposition in higher-order association regions…
Biomimetic in vitro models that more accurately replicate tumor and microenvironmental complexity are transforming radiotherapy research. Unlike traditional 2D cell lines, 3D models such as…
Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner, mediated by muscarinic…
Singhal et al. demonstrate the physiological role of mu-opioid receptor (MORs) in the medial-habenula-to-interpeduncular-nucleus (HP) pathway. Post-synaptic MORs canonically inhibit medial habenula and interpeduncular nucleus…
Many ocean bacteria and protists remain uncultivated with unclear ecosystem roles and interactions. Wittmers et al. worked in the Pacific and beyond to capture active protists…
Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner, mediated by muscarinic…
Biomimetic in vitro models that more accurately replicate tumor and microenvironmental complexity are transforming radiotherapy research. Unlike traditional 2D cell lines, 3D models such as…
